Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG

10-formyl-THFPG → 5,10-methenyl-THFPG + H2O

Reactome: R-HSA-200661
Compartment: cytosol
Rhea: None recorded

Inputs

10-formyl-THFPGCHEBI:28010, (C5H7NO3)n.C25H30N8O10, cytosol

Outputs

5,10-methenyl-THFPGCHEBI:65049, (C5H6NO3)n.C25H26N8O9, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]EC 3.5.4.9

MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG

Inputs

Outputs

Catalysed by

Literature