MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF
5,10-methylene-THF + NAD+ → 5,10-methenyl-THF + NADH
- Reactome
- R-HSA-6801328
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:22893
Inputs
- 5,10-methylene-THFCHEBI:15636, C20H21N7O6, mitochondrial matrix
- NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
Outputs
- 5,10-methenyl-THFCHEBI:57455, C20H20N7O6, mitochondrial matrix
- NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
Catalysed by
- methenyltetrahydrofolate cyclohydrolase activity of MTHFD2, D2L [mitochondrial matrix]EC 3.5.4.9
Literature
- Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues J. Biol. Chem., 2014
- Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues J. Biol. Chem., 2011
- NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene Biochemistry, 1993