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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FOLR2 transports FOLA from extracellular region to cytosol

FOLR2:FOLA → FOLR2 + FOLA

Reactome: R-HSA-8942344
Compartment: extracellular region · plasma membrane · cytosol
Rhea: None recorded

Inputs

FOLR2:FOLAR-HSA-8940118, plasma membrane

Outputs

FOLR2R-HSA-8940133, plasma membrane
FOLACHEBI:62501, C19H17N7O6, cytosol

Literature

Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells J. Biol. Chem., 1985
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition Proc. Natl. Acad. Sci. U.S.A., 2013