PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
5,10-methylene-THF + Gly + H2O → THF + L-Ser
- Reactome
- R-HSA-5694137
- Compartment
- mitochondrial inner membrane · mitochondrial matrix
- Rhea
- RHEA:15482
Inputs
- 5,10-methylene-THFCHEBI:15636, C20H21N7O6, mitochondrial matrix
- GlyCHEBI:57305, C2H5NO2, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
Outputs
- THFCHEBI:57453, C19H21N7O6, mitochondrial matrix
- L-SerCHEBI:33384, C3H7NO3, mitochondrial matrix
Catalysed by
- glycine hydroxymethyltransferase activity of PXLP-K280-SHMT2 tetramer [mitochondrial inner membrane]EC 2.1.2.1
Literature
- Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria Proc. Natl. Acad. Sci. U.S.A., 2011