Mitochondrial FPGS-1 transforms THF to THFPG
THF + 6 ATP + 6 L-Glu → THFPG + 6 ADP + 6 Pi
- Reactome
- R-HSA-200682
- Compartment
- mitochondrial matrix
- Rhea
- None recorded
Inputs
- THFCHEBI:57453, C19H21N7O6, mitochondrial matrix
- 6 ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
- 6 L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
Outputs
- THFPGCHEBI:28624, (C5H7NO3)n.C19H23N7O6, mitochondrial matrix
- 6 ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
- 6 PiCHEBI:43474, HO4P, mitochondrial matrix
Catalysed by
- tetrahydrofolylpolyglutamate synthase activity of FPGS-1 [mitochondrial matrix]EC 6.3.2.17; UniProt Q05932
Literature
- Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure Proc Natl Acad Sci U S A, 1992
- Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene J Biol Chem, 1996