Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FPGS-2 transforms THF to THFPG

THF + 5 ATP + 5 L-Glu → THFPG + 5 ADP + 5 Pi

Reactome: R-HSA-197958
Compartment: cytosol
Rhea: None recorded

Inputs

THFCHEBI:57453, C19H21N7O6, cytosol
5 ATPCHEBI:30616, C10H12N5O13P3, cytosol
5 L-GluCHEBI:29985, C5H8NO4, cytosol

Outputs

THFPGCHEBI:28624, (C5H7NO3)n.C19H23N7O6, cytosol
5 ADPCHEBI:456216, C10H12N5O10P2, cytosol
5 PiCHEBI:43474, HO4P, cytosol

Catalysed by

tetrahydrofolylpolyglutamate synthase activity of FPGS-2 [cytosol]EC 6.3.2.17; UniProt Q05932

Literature

Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure Proc Natl Acad Sci U S A, 1992
Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene J Biol Chem, 1996