Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

5,10-methylene-THFPG + NADPH + H+ → 5-methyl-THFPG + NADP+

Reactome: R-HSA-200676
Compartment: cytosol
Rhea: None recorded

Inputs

5,10-methylene-THFPGCHEBI:60473, (C5H6NO3)n.C15H15N6O3, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

5-methyl-THFPGCHEBI:63907, (C5H7NO3)n.C25H32N8O9, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

methylenetetrahydrofolate reductase [NAD(P)H] activity of MTHFR dimer [cytosol]EC 1.5.1.20

Literature

Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency Am J Hum Genet, 1995