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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

5-formyl-THFPG + ATP → 5,10-methenyl-THFPG + ADP + Pi + H+

Reactome: R-HSA-6801342
Compartment: cytosol
Rhea: None recorded

Inputs

5-formyl-THFPGCHEBI:63907, (C5H7NO3)n.C25H32N8O9, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

5,10-methenyl-THFPGCHEBI:65049, (C5H6NO3)n.C25H26N8O9, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
PiCHEBI:43474, HO4P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

5-formyltetrahydrofolate cyclo-ligase activity of MTHFS [cytosol]EC 6.3.3.2; UniProt P49914

Literature

Cloning and characterization of the human 5,10-methenyltetrahydrofolate synthetase-encoding cDNA Gene, 1995
Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates Biochim. Biophys. Acta, 1987