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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Sulfur amino acids

Methionine, cysteine, transsulfuration and related sulfur-transfer chemistry. 36 reactions, from Reactome R-HSA-1614635.

  1. Methylthio-ribose-P => Methylthio-ribulose-PMTRIBP → MTRIBUP
  2. Transamination of MOB to methionine4MTOBUTA + L-amino acid → L-Met + 2-Oxoacid
  3. Acireductone is oxidized to MOBAcireductone + O2 → 4MTOBUTA + HCOOH + 2 H+
  4. Acireductone is created2,3-DMPP + H2O → Acireductone + Pi
  5. Dehydration of methylthio-ribulose-PMTRIBUP → 2,3-DMPP + H2O
  6. MTA is cleaved and phosphorylatedMTAD + Pi → MTRIBP + Ade
  7. Methylthio-ribulose-P => Methylthio-ribose-PMTRIBUP → MTRIBP
  8. PXLP-CBS tetramers condenses HCYS and L-Ser to form L-CystathionineHCYS + L-Ser → L-Cystathionine + H2O
  9. Sulfite is oxidized to sulfatesulfite(2-) + O2 + H2O → SO4(2-) + H2O2
  10. Sulfate is exported to the cytosol in exchange for dicarboxylateMAL + SO4(2-) → MAL + SO4(2-)
  11. Excess homocysteine yields homolanthionine and H2S2 HCYS → HLAN + H2S + H+
  12. PXLP-K212-CTH cleaves L-CystathionineL-Cystathionine + H2O → L-Cys + 2OBUTA + NH4+
  13. Excess cysteine yields lanthionine and H2S2 L-Cys → L-Lanthionine + H2S + H+
  14. Persulfide sulfur is dioxygenated2 CysS-SQRDL(1-450) + 2 H2O + 2 O2 → 4 H+ + 2 sulfite(2-) + 2 SQRDL(1-450)
  15. Cysteine is degraded to pyruvate and H2SH2O + L-Cys → H+ + NH4+ + PYR + H2S
  16. Persulfide sulfur is transferred onto sulfite2 CysS-SQRDL(1-450) + 2 sulfite(2-) → 2 SQRDL(1-450) + 2 S2O3(2-)
  17. Homocysteine is degraded to oxobutanoate and H2SHCYS + H2O → 2OBUTA + H2S + NH4+ + H+
  18. CDO1:Fe2+ oxidises L-Cys to 3-SulfinoalanineL-Cys + O2 → 3-Sulfinoalanine + H+
  19. BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLYBET + HCYS → DMGLY + L-Met
  20. SQR oxidizes sulfide to bound persulfide2 2xHC-SQRDL(1-450) + 2 H2S + 2 CoQ + 4 H+ → 2 CysS-SQRDL(1-450) + 2 QH2
  21. PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine3-Sulfinoalanine + H+ → HTAU + CO2
  22. FMO1:FAD oxidizes HTAU to TAUHTAU + H+ + NADPH + O2 → TAU + H2O + NADP+
  23. Thiosulfate can transfer its sulfur atom to glutathioneS2O3(2-) + H+ + 2 GSH → H+ + sulfite(2-) + S-sulfanylglutathionate
  24. MTR transfers CH3 from MeCbl to HCYSMTRR:MTR:MeCbl + HCYS → MTRR:MTR:cob(I)alamin + L-Met
  25. MAT1A multimers transfer Ado from ATP to L-MetATP + L-Met + H2O → AdoMet + Pi + PPi
  26. AHCY:NAD+ tetramer hydrolyses AdoHcyAdoHcy + H2O → HCYS + Ade-Rib
  27. BHMT2 tetramer transfers CH3 group from SMM to LHCYSSMM + HCYS → 2 L-Met + H+
  28. ADO oxidises 2AET to HTAU2AET + O2 → HTAU + H+
  29. PXLP-K333-GADL1 decarboxylates CSA to HTAUCSA + H+ → HTAU + CO2
  30. GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and GluL-Cys + 2OG → 3MPYR + L-Glu
  31. MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR3MPYR + HSO3- → S2O3(2-) + PYR
  32. TST transfers sulfur from S2O3(2-) to HCN to form HSCNS2O3(2-) + HCN → HSCN + SO3(2-) + 2 H+
  33. MPST transfers sulfur from 3MPYR to HCN to form HSCN3MPYR + HCN → HSCN + PYR
  34. MPST transfers sulfur from sulfanegen to HCN to form HSCNsulfanegen + 2 HCN → 2 HSCN + 2 PYR
  35. MPST transfers sulfur atom from 3MPYR to form CysS248-MPST3MPYR + MPST → CysS248-MPST + PYR
  36. MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPSTTXN2 + CysS248-MPST → MPST + 2xHC-TXN2 + disulfanide