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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST

TXN2 + CysS248-MPST → MPST + 2xHC-TXN2 + disulfanide

Reactome: R-HSA-9035484
Compartment: mitochondrial matrix
Rhea: RHEA:56301

Inputs

TXN2R-HSA-3323048, mitochondrial matrix
CysS248-MPSTR-HSA-9034913, mitochondrial matrix

Outputs

MPSTR-HSA-9012720, mitochondrial matrix
2xHC-TXN2R-HSA-3323059, mitochondrial matrix
disulfanideCHEBI:30604, HS2, mitochondrial matrix

Catalysed by

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor of CysS248-MPST:TXN2 [mitochondrial matrix]EC 1.8.4

Literature

Polysulfides are possible H2S-derived signaling molecules in rat brain FASEB J., 2013
3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S Sci Rep, 2017
Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection Free Radic. Biol. Med., 2017
Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2 Protein Sci., 2005
Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase J. Biol. Chem., 2013