Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Persulfide sulfur is transferred onto sulfite

2 CysS-SQRDL(1-450) + 2 sulfite(2-) → 2 SQRDL(1-450) + 2 S2O3(2-)

Reactome: R-HSA-1614618
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

2 CysS-SQRDL(1-450)R-HSA-1614576, mitochondrial inner membrane
2 sulfite(2-)CHEBI:17359, O3S, mitochondrial matrix

Outputs

2 SQRDL(1-450)R-HSA-1614646, mitochondrial inner membrane
2 S2O3(2-)CHEBI:33542, HO3S2, mitochondrial matrix

Catalysed by

sulfurtransferase activity of TST [mitochondrial matrix]EC 2.8.1; UniProt Q16762

Literature

Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria FEBS J, 2008