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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MPST transfers sulfur from 3MPYR to HCN to form HSCN

3MPYR + HCN → HSCN + PYR

Reactome: R-HSA-9013471
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

3MPYRCHEBI:57678, C3H3O3S, mitochondrial matrix
HCNCHEBI:18407, CHN, mitochondrial matrix

Outputs

HSCNCHEBI:18022, CNS, mitochondrial matrix
PYRCHEBI:15361, C3H3O3, mitochondrial matrix

Catalysed by

sulfurtransferase activity of MPST [mitochondrial matrix]EC 2.8.1; UniProt P25325

Literature

Enzymatic conversion of cyanide to thiocyanate Am. J. Physiol., 1948
A partial exploration of the potential energy surfaces of SCN and HSCN: implications for the enzyme-mediated detoxification of cyanide J. Mol. Graph. Model., 2009
In-vitro mercaptopyruvate sulfurtransferase species comparison in humans and common laboratory animals Toxicol. Lett., 2017