Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MPST transfers sulfur atom from 3MPYR to form CysS248-MPST

3MPYR + MPST → CysS248-MPST + PYR

Reactome: R-HSA-9034756
Compartment: mitochondrial matrix
Rhea: RHEA:56297

Inputs

3MPYRCHEBI:57678, C3H3O3S, mitochondrial matrix
MPSTR-HSA-9012720, mitochondrial matrix

Outputs

CysS248-MPSTR-HSA-9034913, mitochondrial matrix
PYRCHEBI:15361, C3H3O3, mitochondrial matrix

Catalysed by

sulfurtransferase activity of MPST [mitochondrial matrix]EC 2.8.1; UniProt P25325

Literature

Polysulfides are possible H2S-derived signaling molecules in rat brain FASEB J., 2013
Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain Sci Rep, 2015
Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection Free Radic. Biol. Med., 2017
Hydrogen polysulfide (H2S n ) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO) J Neural Transm (Vienna), 2016