PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine
HCYS + L-Ser → L-Cystathionine + H2O
- Reactome
- R-HSA-1614524
- Compartment
- cytosol
- Rhea
- RHEA:10113
Inputs
- HCYSCHEBI:58199, C4H9NO2S, cytosol
- L-SerCHEBI:33384, C3H7NO3, cytosol
Outputs
- L-CystathionineCHEBI:58161, C7H14N2O4S, cytosol
- H2OCHEBI:15377, H2O, cytosol
Catalysed by
- cystathionine beta-synthase activity of PXLP-K119-CBS tetramer [cytosol]EC 4.2.1.22
Literature
- Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region Biochemistry, 2001
- Binding of pyridoxal 5'-phosphate to the heme protein human cystathionine beta-synthase Biochemistry, 1999