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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PXLP-K333-GADL1 decarboxylates CSA to HTAU

CSA + H+ → HTAU + CO2

Reactome: R-HSA-6814165
Compartment: cytosol
Rhea: RHEA:16878

Inputs

CSACHEBI:61085, C3H6NO4S, cytosol
H+CHEBI:15378, H, cytosol

Outputs

HTAUCHEBI:57853, C2H7NO2S, cytosol
CO2CHEBI:16526, CO2, cytosol

Catalysed by

carboxy-lyase activity of PXLP-K333-GADL1 dimer [cytosol]EC 4.1.1

Literature

Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis J. Biol. Chem., 2012
Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid α-decarboxylases Amino Acids, 2013
Structure of the mouse acidic amino acid decarboxylase GADL1 Acta Crystallogr F Struct Biol Commun, 2018