SQR oxidizes sulfide to bound persulfide
2 2xHC-SQRDL(1-450) + 2 H2S + 2 CoQ + 4 H+ → 2 CysS-SQRDL(1-450) + 2 QH2
- Reactome
- R-HSA-1614665
- Compartment
- mitochondrial inner membrane · cytosol
- Rhea
- None recorded
Inputs
- 2 2xHC-SQRDL(1-450)R-HSA-1614613, mitochondrial inner membrane
- 2 H2SCHEBI:29919, HS, cytosol
- 2 CoQCHEBI:46245, C59H90O4, mitochondrial inner membrane
- 4 H+CHEBI:15378, H, mitochondrial inner membrane
Outputs
- 2 CysS-SQRDL(1-450)R-HSA-1614576, mitochondrial inner membrane
- 2 QH2CHEBI:17976, (C5H8)n.C9H12O4, mitochondrial inner membrane
Catalysed by
- sulfide:quinone oxidoreductase activity of SQR:FAD [mitochondrial inner membrane]EC 1.8.5.4
Literature
- Single eubacterial origin of eukaryotic sulfide:quinone oxidoreductase, a mitochondrial enzyme conserved from the early evolution of eukaryotes during anoxic and sulfidic times Mol Biol Evol, 2003
- Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria FEBS J, 2008