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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Sulfite is oxidized to sulfate

sulfite(2-) + O2 + H2O → SO4(2-) + H2O2

Reactome: R-HSA-1614544
Compartment: mitochondrial matrix
Rhea: RHEA:24601

Inputs

sulfite(2-)CHEBI:17359, O3S, mitochondrial matrix
O2CHEBI:15379, O2, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

SO4(2-)CHEBI:16189, O4S, mitochondrial matrix
H2O2CHEBI:16240, H2O2, mitochondrial matrix

Catalysed by

sulfite oxidase activity of holo-SUOX [mitochondrial matrix]EC 1.8.3.1

Literature

The G473D mutation impairs dimerization and catalysis in human sulfite oxidase Biochemistry, 2006
Sulfite oxidizing enzymes Biochim Biophys Acta, 2007