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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MTA is cleaved and phosphorylated

MTAD + Pi → MTRIBP + Ade

Reactome: R-HSA-1237160
Compartment: cytosol
Rhea: RHEA:11853

Inputs

MTADCHEBI:17509, C11H15N5O3S, cytosol
PiCHEBI:43474, HO4P, cytosol

Outputs

MTRIBPCHEBI:58533, C6H11O7PS, cytosol
AdeCHEBI:16708, C5H5N5, cytosol

Catalysed by

S-methyl-5-thioadenosine phosphorylase activity of MTAP trimer [cytosol]EC 2.4.2.28

Literature

Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme Proc Natl Acad Sci U S A, 1981
Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta J Biol Chem, 1986
Primate Genome Gain and Loss: A Bone Dysplasia, Muscular Dystrophy, and Bone Cancer Syndrome Resulting from Mutated Retroviral-Derived MTAP Transcripts Am J Hum Genet, 2012