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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FMO1:FAD oxidizes HTAU to TAU

HTAU + H+ + NADPH + O2 → TAU + H2O + NADP+

Reactome: R-HSA-1655453
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:69820

Inputs

HTAUCHEBI:57853, C2H7NO2S, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

TAUCHEBI:507393, C2H7NO3S, cytosol
H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

hypotaurine monooxygenase activity of FMO1:FAD [endoplasmic reticulum membrane]EC 1.14.13.8

Literature

Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine Drug Metab Dispos, 2020