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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu

L-Cys + 2OG → 3MPYR + L-Glu

Reactome: R-HSA-9012597
Compartment: mitochondrial matrix
Rhea: RHEA:17442

Inputs

L-CysCHEBI:35235, C3H7NO2S, mitochondrial matrix
2OGCHEBI:16810, C5H4O5, mitochondrial matrix

Outputs

3MPYRCHEBI:57678, C3H3O3S, mitochondrial matrix
L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix

Catalysed by

L-cysteine:2-oxoglutarate transaminase activity of GOT2 dimer [mitochondrial matrix]EC 2.6.1.3

Literature

Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells Hepatology, 1998