TST transfers sulfur from S2O3(2-) to HCN to form HSCN
S2O3(2-) + HCN → HSCN + SO3(2-) + 2 H+
- Reactome
- R-HSA-9013198
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:16881, RHEA:16882
Inputs
- S2O3(2-)CHEBI:33542, HO3S2, mitochondrial matrix
- HCNCHEBI:18407, CHN, mitochondrial matrix
Outputs
- HSCNCHEBI:18022, CNS, mitochondrial matrix
- SO3(2-)CHEBI:17359, O3S, mitochondrial matrix
- 2 H+CHEBI:15378, H, peroxisomal matrix
Catalysed by
- thiosulfate-cyanide sulfurtransferase activity of TST [mitochondrial matrix]EC 2.8.1.1; UniProt Q16762
Literature
- Enzymatic conversion of cyanide to thiocyanate Am. J. Physiol., 1948
- Cloning and expression of human liver rhodanese cDNA Biochem. Biophys. Res. Commun., 1997
- A partial exploration of the potential energy surfaces of SCN and HSCN: implications for the enzyme-mediated detoxification of cyanide J. Mol. Graph. Model., 2009