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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Thiosulfate can transfer its sulfur atom to glutathione

S2O3(2-) + H+ + 2 GSH → H+ + sulfite(2-) + S-sulfanylglutathionate

Reactome: R-HSA-1655879
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

S2O3(2-)CHEBI:33542, HO3S2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix
2 GSHCHEBI:16856, C10H17N3O6S, mitochondrial matrix

Outputs

H+CHEBI:15378, H, mitochondrial matrix
sulfite(2-)CHEBI:17359, O3S, mitochondrial matrix
S-sulfanylglutathionateCHEBI:58905, C10H16N3O6S2, mitochondrial matrix

Catalysed by

thiosulfate-thiol sulfurtransferase activity of TSTD1 [cytosol]EC 2.8.1.3; UniProt Q8NFU3

Literature

The catalytic mechanism of yeast thiosulfate reductase J Biol Chem, 1983
Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog Biochemistry, 2014