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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Homocysteine is degraded to oxobutanoate and H2S

HCYS + H2O → 2OBUTA + H2S + NH4+ + H+

Reactome: R-HSA-1614631
Compartment: cytosol
Rhea: RHEA:14502

Inputs

HCYSCHEBI:58199, C4H9NO2S, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

2OBUTACHEBI:16763, C4H5O3, cytosol
H2SCHEBI:29919, HS, cytosol
NH4+CHEBI:28938, H4N, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

homocysteine desulfhydrase activity of PXLP-K212-CTH tetramer [cytosol]EC 4.4.1.2

Homocysteine is degraded to oxobutanoate and H2S

Inputs

Outputs

Catalysed by

Literature