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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MPST transfers sulfur from sulfanegen to HCN to form HSCN

sulfanegen + 2 HCN → 2 HSCN + 2 PYR

Reactome: R-HSA-9013533
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

sulfanegenR-ALL-9013543, mitochondrial matrix
2 HCNCHEBI:18407, CHN, mitochondrial matrix

Outputs

2 HSCNCHEBI:18022, CNS, mitochondrial matrix
2 PYRCHEBI:15361, C3H3O3, mitochondrial matrix

Catalysed by

sulfurtransferase activity of MPST [mitochondrial matrix]EC 2.8.1; UniProt P25325

Literature

Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification? Curr. Drug Targets Immune Endocr. Metabol. Disord., 2003