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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Persulfide sulfur is dioxygenated

2 CysS-SQRDL(1-450) + 2 H2O + 2 O2 → 4 H+ + 2 sulfite(2-) + 2 SQRDL(1-450)

Reactome: R-HSA-1614605
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

2 CysS-SQRDL(1-450)R-HSA-1614576, mitochondrial inner membrane
2 H2OCHEBI:15377, H2O, mitochondrial matrix
2 O2CHEBI:15379, O2, mitochondrial matrix

Outputs

4 H+CHEBI:15378, H, mitochondrial matrix
2 sulfite(2-)CHEBI:17359, O3S, mitochondrial matrix
2 SQRDL(1-450)R-HSA-1614646, mitochondrial inner membrane

Catalysed by

sulfur dioxygenase activity of ETHE1:2Zn2+ [mitochondrial matrix]EC 1.13.11.18

Literature

Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy Nat Med, 2009