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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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PXLP-K212-CTH cleaves L-Cystathionine

L-Cystathionine + H2O → L-Cys + 2OBUTA + NH4+

Reactome
R-HSA-1614583
Compartment
cytosol
Rhea
RHEA:14006

Inputs

Outputs

Catalysed by

  • cystathionine gamma-lyase activity of PXLP-K212-CTH tetramer [cytosol]EC 4.4.1.1

Literature

  1. H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia J Biol Chem, 2009
  2. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration J Biol Chem, 1999