PXLP-K212-CTH cleaves L-Cystathionine
L-Cystathionine + H2O → L-Cys + 2OBUTA + NH4+
- Reactome
- R-HSA-1614583
- Compartment
- cytosol
- Rhea
- RHEA:14006
Inputs
- L-CystathionineCHEBI:58161, C7H14N2O4S, cytosol
- H2OCHEBI:15377, H2O, cytosol
Outputs
- L-CysCHEBI:35235, C3H7NO2S, cytosol
- 2OBUTACHEBI:16763, C4H5O3, cytosol
- NH4+CHEBI:28938, H4N, cytosol
Catalysed by
- cystathionine gamma-lyase activity of PXLP-K212-CTH tetramer [cytosol]EC 4.4.1.1
Literature
- H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia J Biol Chem, 2009
- Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration J Biol Chem, 1999