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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Pyruvate metabolism

Routes that move, reduce, oxidize or carboxylate pyruvate at the junction of carbohydrate, amino-acid and mitochondrial metabolism. 31 reactions, from Reactome R-HSA-70268.

  1. PDK isozymes phosphorylate PDHC subunit E1PDH complex + 2 ATP → p-lipo-PDH + 2 ADP + H+
  2. PDP1,2 dephosphorylate p-lipo-PDH2 H2O + p-lipo-PDH → PDH complex + 2 Pi
  3. MPC1:MPC2 imports PYR, H+ to mitochondrial matrixH+ + PYR → H+ + PYR
  4. GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSHGSH + MGXL → (R)-S-LGSH
  5. HAGH hydrolyses (R)-S-LGSH to GSH and LACT(R)-S-LGSH + H2O → H+ + D-LACT + (2Fe-2S)(1+)
  6. LDHAL6B reduces PYR to LACTPYR + NADH + H+ → LACT + NAD+
  7. PC carboxylates PYR to OAATP + PYR + HCO3- → ADP + Pi + OA + H+
  8. LDH tetramer oxidises LACT to PYRLACT + NAD+ → PYR + NADH + H+
  9. PXLP-K314-GPT transaminates L-Ala to form PYRL-Ala + 2OG → PYR + L-Glu
  10. Pyruvate kinase dephosphorylates PEP to PYRADP + PEP + H+ → ATP + PYR
  11. LDH tetramer reduces PYR to LACTPYR + NADH + H+ → LACT + NAD+
  12. DCA binds PDK2DCA + PDK2(?-407) → DCA:PDK2
  13. GSTZ1 dimer dehalogenates DCADCA + GSH → GS-MCA + Cl- + H+
  14. FAHD1 dimer hydrolyses OA to PYROA + H+ → PYR + CO2
  15. ME1 tetramer decarboxylates MAL to PYRMAL + NADP+ → PYR + CO2 + NADPH + H+
  16. ME2 tetramer decarboxylates MAL to PYRMAL + NAD+ → PYR + CO2 + NADH
  17. ME3 tetramer decarboxylates MAL to PYRMAL + NADP+ → PYR + CO2 + NADPH
  18. VDAC1 transports PYR from cytosol to mitochondrial intermembrane spacePYR → PYR
  19. CTLH E3 ligase ubiquitinates LDHALDHA + Ub → PolyUb-LDHA
  20. Cytosolic H2O2 decarboxylates PYR to acetatePYR + H2O2 → H2O + CO2 + acetate
  21. DLD dimer dehydrogenates dihydrolipoylNAD+ + LipoH2-K259-DLAT → H+ + NADH + Lipo-K259-DLAT
  22. SIRT4 cleaves lipoyl from DLATH2O + Lipo-K259-DLAT + NAD+ → 2''-O-lipoyl-ADP-D-ribose + NAM + DLAT
  23. ME1 tetramerizes4 ME1 + 4 Mg2+/Mn2+ → ME1 tetramer
  24. CTLH E3 ligase ubiquitinates PKM-1Ub + PKM-1 → PolyUb-PKM-1
  25. NEK1 phosphorylates ME1ME1 + ATP → p-S336-ME1 + ADP + H+
  26. ME1 tetramer decarboxylates OA to PYROA + H+ → PYR + CO2
  27. DLAT trimer transfers acetyl to CoACoA-SH + AcetyllipoH2-K132,K259-DLAT → Ac-CoA + LipoH2-K259-DLAT
  28. PGAM5 dodecamer dephosphorylates p-S336-ME1H2O + p-S336-ME1 → Pi + ME1
  29. PDH E1 decarboxylates PYR, transferring acetyl to DLATPYR + Lipo-K259-DLAT + H+ → AcetyllipoH2-K132,K259-DLAT + CO2
  30. Mitochondrial H2O2 decarboxylates PYR to acetateH2O2 + PYR → CO2 + H2O + CH3COO-
  31. GS-MCA spontaneously hydrolyzesGS-MCA + H2O → GSH + glyoxylate + H+ + Cl-