MPC1:MPC2 imports PYR, H+ to mitochondrial matrix
H+ + PYR → H+ + PYR
- Reactome
- R-HSA-372342
- Compartment
- mitochondrial intermembrane space · mitochondrial inner membrane · mitochondrial matrix
- Rhea
- RHEA:64720, RHEA:64721
Inputs
- H+CHEBI:15378, H, mitochondrial intermembrane space
- PYRCHEBI:15361, C3H3O3, mitochondrial intermembrane space
Outputs
- H+CHEBI:15378, H, mitochondrial matrix
- PYRCHEBI:15361, C3H3O3, mitochondrial matrix
Catalysed by
- pyruvate transmembrane transporter activity of MPC dimer [mitochondrial inner membrane]
Literature
- A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans Science, 2012
- Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate Biochem. J., 1974
- The transport of pyruvate in rat liver mitochondria FEBS Lett, 1971
- MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells J Biol Chem, 2016
- Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier Biology (Basel), 2020
- Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases Int J Mol Sci, 2020