ME3 tetramer decarboxylates MAL to PYR
MAL + NADP+ → PYR + CO2 + NADPH
- Reactome
- R-HSA-9012349
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:18254
Inputs
- MALCHEBI:15589, C4H4O5, mitochondrial matrix
- NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
Outputs
- PYRCHEBI:15361, C3H3O3, mitochondrial matrix
- CO2CHEBI:16526, CO2, mitochondrial matrix
- NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
Catalysed by
- malate dehydrogenase (decarboxylating) (NADP+) activity of ME3:Mg2+ tetramer [mitochondrial matrix]EC 1.1.1.40
Literature
- Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme Biochem. J., 1994
- Structure and function of malic enzymes, a new class of oxidative decarboxylases Biochemistry, 2003
- Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells Mol. Endocrinol., 2015
- Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme PLoS ONE, 2012
- Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer Heliyon, 2022
- The Pancreatic β-Cell: The Perfect Redox System Antioxidants (Basel), 2021