PXLP-K314-GPT transaminates L-Ala to form PYR
L-Ala + 2OG → PYR + L-Glu
- Reactome
- R-HSA-70523
- Compartment
- cytosol
- Rhea
- RHEA:19454
Inputs
- L-AlaCHEBI:57972, C3H7NO2, cytosol
- 2OGCHEBI:16810, C5H4O5, cytosol
Outputs
- PYRCHEBI:15361, C3H3O3, cytosol
- L-GluCHEBI:29985, C5H8NO4, cytosol
Catalysed by
- L-alanine:2-oxoglutarate transaminase activity of PXLP-K314-GPT dimer [cytosol]EC 2.6.1.2
Literature
- Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods Biochemistry, 1991
- Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites. Genomics, 1997
- cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase Genomics, 2002