DLAT trimer transfers acetyl to CoA
CoA-SH + AcetyllipoH2-K132,K259-DLAT → Ac-CoA + LipoH2-K259-DLAT
- Reactome
- R-HSA-9861667
- Compartment
- mitochondrial inner membrane · mitochondrial matrix
- Rhea
- RHEA:17019
Inputs
- CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
- AcetyllipoH2-K132,K259-DLATR-HSA-9861594, mitochondrial matrix
Outputs
- Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix
- LipoH2-K259-DLATR-HSA-9861664, mitochondrial matrix
Catalysed by
- dihydrolipoyllysine-residue acetyltransferase activity of PDH complex [mitochondrial matrix]EC 2.3.1.12
Literature
- Assembly and full functionality of recombinantly expressed dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex J Biol Chem, 1997
- Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase Proc Natl Acad Sci U S A, 1988
- Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency Ann Neurol, 2005