Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PDH E1 decarboxylates PYR, transferring acetyl to DLAT

PYR + Lipo-K259-DLAT + H+ → AcetyllipoH2-K132,K259-DLAT + CO2

Reactome: R-HSA-9861734
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: RHEA:19190

Inputs

PYRCHEBI:15361, C3H3O3, mitochondrial matrix
Lipo-K259-DLATR-HSA-69969, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Outputs

AcetyllipoH2-K132,K259-DLATR-HSA-9861594, mitochondrial matrix
CO2CHEBI:16526, CO2, mitochondrial matrix

Catalysed by

pyruvate dehydrogenase (acetyl-transferring) activity of PDH complex [mitochondrial matrix]EC 1.2.4.1

Literature

Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase J Biol Chem, 2003
Pyruvate dehydrogenase deficiency and epilepsy Brain Dev, 2011