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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HAGH hydrolyses (R)-S-LGSH to GSH and LACT

(R)-S-LGSH + H2O → H+ + D-LACT + (2Fe-2S)(1+)

Reactome: R-HSA-6783221
Compartment: cytosol
Rhea: RHEA:25246

Inputs

(R)-S-LGSHCHEBI:57474, C13H20N3O8S, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

H+CHEBI:15378, H, cytosol
D-LACTCHEBI:16004, C3H5O3, cytosol
(2Fe-2S)(1+)CHEBI:33738, Fe2S2, cytosol

Catalysed by

hydroxyacylglutathione hydrolase activity of HAGH-2:2xZn2+ [cytosol]EC 3.1.2.6

Literature

Molecular cloning, heterologous expression, and characterization of human glyoxalase II J. Biol. Chem., 1996
The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II J. Biol. Chem., 2004
Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue Structure, 1999