Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LDHAL6B reduces PYR to LACT

PYR + NADH + H+ → LACT + NAD+

Reactome: R-HSA-6807826
Compartment: mitochondrial matrix
Rhea: RHEA:23446, RHEA:23447

Inputs

PYRCHEBI:15361, C3H3O3, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Outputs

LACTCHEBI:422, C3H6O3, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Catalysed by

L-lactate dehydrogenase (NAD+) activity of LDHAL6B [mitochondrial matrix]EC 1.1.1.27; UniProt Q9BYZ2

Literature

Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs Comput Biol Chem, 2009
Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis Int. J. Mol. Med., 2005