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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LDH tetramer oxidises LACT to PYR

LACT + NAD+ → PYR + NADH + H+

Reactome: R-HSA-70510
Compartment: cytosol
Rhea: RHEA:23445

Inputs

LACTCHEBI:16651, C3H5O3, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

PYRCHEBI:15361, C3H3O3, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

L-lactate dehydrogenase (NAD+) activity of LDH tetramer [cytosol]EC 1.1.1.27

Literature

Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA) Mol. Biol. Rep., 2009
Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli Biochem. J., 1991
Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence Proc. Natl. Acad. Sci. U.S.A., 1987
Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase Proteins, 2001
The cDNA and protein sequences of human lactate dehydrogenase B Biochem J, 1987
Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4 Biochem Pharmacol, 2001