PDK isozymes phosphorylate PDHC subunit E1
PDH complex + 2 ATP → p-lipo-PDH + 2 ADP + H+
- Reactome
- R-HSA-203946
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:23053
Inputs
- PDH complexR-HSA-70070, mitochondrial matrix
- 2 ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
Outputs
- p-lipo-PDHR-HSA-210342, mitochondrial matrix
- 2 ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Catalysed by
- pyruvate dehydrogenase (acetyl-transferring) kinase activity of PDK isozyme dimers [mitochondrial matrix]EC 2.7.11.2
Literature
- Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex Biochem J, 1998
- Diversity of the pyruvate dehydrogenase kinase gene family in humans J Biol Chem, 1995
- Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites Biochem J, 2001
- Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase J Biol Chem, 2001
- Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human J Biol Chem, 1996
- Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications Biosci Rep, 2021