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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PDP1,2 dephosphorylate p-lipo-PDH

2 H2O + p-lipo-PDH → PDH complex + 2 Pi

Reactome: R-HSA-204169
Compartment: mitochondrial matrix
Rhea: RHEA:12670

Inputs

2 H2OCHEBI:15377, H2O, mitochondrial matrix
p-lipo-PDHR-HSA-210342, mitochondrial matrix

Outputs

PDH complexR-HSA-70070, mitochondrial matrix
2 PiCHEBI:43474, HO4P, mitochondrial matrix

Catalysed by

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity of PDP [mitochondrial matrix]EC 3.1.3.43

Literature

Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation J Biol Chem, 1998
Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase J Biol Chem, 1997
Pyruvate dehydrogenase phosphatase deficiency: identification of the first mutation in two brothers and restoration of activity by protein complementation J Clin Endocrinol Metab, 2005
Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications J Mol Biol, 2007
Pyruvate dehydrogenase phosphatase deficiency: orphan disease or an under-diagnosed condition? Mol Cell Endocrinol, 2006