Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CTLH E3 ligase ubiquitinates LDHA

LDHA + Ub → PolyUb-LDHA

Reactome: R-HSA-9861563
Compartment: cytosol
Rhea: None recorded

Inputs

LDHAR-HSA-70502, cytosol
UbR-HSA-113595, cytosol

Outputs

PolyUb-LDHAR-HSA-9861549, cytosol

Catalysed by

ubiquitin-protein transferase activity of CTLH E3 ligase [cytosol]EC 6.3.2.19

CTLH E3 ligase ubiquitinates LDHA

Inputs

Outputs

Catalysed by

Literature