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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GSTZ1 dimer dehalogenates DCA

DCA + GSH → GS-MCA + Cl- + H+

Reactome: R-HSA-9011595
Compartment: mitochondrial matrix
Rhea: RHEA:16438

Inputs

DCAR-ALL-9010792, mitochondrial matrix
GSHCHEBI:16856, C10H17N3O6S, mitochondrial matrix

Outputs

GS-MCACHEBI:229639, C12H17ClN3O8S, mitochondrial matrix
Cl-CHEBI:17996, Cl, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

glutathione transferase activity of GSTZ1 dimer [mitochondrial matrix]EC 2.5.1.18

Literature

Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1 J. Pharmacol. Exp. Ther., 2011
Pharmacokinetics, metabolism and toxicology of dichloroacetate Drug Metab. Rev., 1998
Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity. Biochemistry, 2001
Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a) Acta Crystallogr F Struct Biol Commun, 2014
Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids Chem Res Toxicol, 1998