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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ME1 tetramer decarboxylates OA to PYR

OA + H+ → PYR + CO2

Reactome: R-HSA-9861660
Compartment: cytosol
Rhea: RHEA:15642

Inputs

OACHEBI:16452, C4H2O5, cytosol
H+CHEBI:15378, H, cytosol

Outputs

PYRCHEBI:15361, C3H3O3, cytosol
CO2CHEBI:16526, CO2, cytosol

Catalysed by

oxaloacetate decarboxylase activity of ME1 tetramer [cytosol]EC 4.1.1.112

Literature

Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain Int J Biochem Cell Biol, 1995
Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme Eur. J. Biochem., 1991
Structure and function of malic enzymes, a new class of oxidative decarboxylases Biochemistry, 2003
Structural characteristics of the nonallosteric human cytosolic malic enzyme Biochim. Biophys. Acta, 2014
Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme PLoS ONE, 2012