VDAC1 transports PYR from cytosol to mitochondrial intermembrane space

PYR → PYR

Reactome

R-HSA-9012374

Compartment

cytosol · mitochondrial intermembrane space · mitochondrial outer membrane

Rhea

None recorded

Catalysed by

• voltage-gated monoatomic anion channel activity of VDAC1 [mitochondrial outer membrane]UniProt P21796

Literature

1. Deficiency of the voltage-dependent anion channel: a novel cause of mitochondriopathy Pediatr. Res., 1996
2. Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel FEBS Lett, 2011
3. Structure and Gating Behavior of the Human Integral Membrane Protein VDAC1 in a Lipid Bilayer J Am Chem Soc, 2022
4. The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease Cells, 2021
5. Mitochondrial pyruvate transport: a historical perspective and future research directions Biochem. J., 2015