ME1 tetramer decarboxylates MAL to PYR
MAL + NADP+ → PYR + CO2 + NADPH + H+
- Reactome
- R-HSA-9012036
- Compartment
- cytosol
- Rhea
- RHEA:18254
Inputs
- MALCHEBI:15589, C4H4O5, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Outputs
- PYRCHEBI:15361, C3H3O3, cytosol
- CO2CHEBI:16526, CO2, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- malate dehydrogenase (decarboxylating) (NADP+) activity of ME1 tetramer [cytosol]EC 1.1.1.40
Literature
- Malic enzyme in human liver. Intracellular distribution, purification and properties of cytosolic isozyme Eur. J. Biochem., 1991
- Structure and function of malic enzymes, a new class of oxidative decarboxylases Biochemistry, 2003
- Structural characteristics of the nonallosteric human cytosolic malic enzyme Biochim. Biophys. Acta, 2014
- Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme PLoS ONE, 2012
- Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism J Mol Endocrinol, 2020
- Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain Int J Biochem Cell Biol, 1995