Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NEK1 phosphorylates ME1

ME1 + ATP → p-S336-ME1 + ADP + H+

Reactome: R-HSA-9861642
Compartment: cytosol
Rhea: RHEA:17990

Inputs

ME1R-HSA-400119, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

p-S336-ME1R-HSA-9861606, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

protein serine/threonine kinase activity of NEK1:Mg2+ [cytosol]EC 2.7.11.1

NEK1 phosphorylates ME1

Inputs

Outputs

Catalysed by

Literature