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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PGAM5 dodecamer dephosphorylates p-S336-ME1

H2O + p-S336-ME1 → Pi + ME1

Reactome: R-HSA-9861725
Compartment: cytosol · mitochondrial outer membrane
Rhea: RHEA:20630

Inputs

H2OCHEBI:15377, H2O, cytosol
p-S336-ME1R-HSA-9861606, cytosol

Outputs

PiCHEBI:43474, HO4P, cytosol
ME1R-HSA-400119, cytosol

Catalysed by

protein serine/threonine phosphatase activity of PGAM5 dodecamer [mitochondrial outer membrane]EC 3.1.3.16

Literature

Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis Mol Cell, 2020
Functional role of PGAM5 multimeric assemblies and their polymerization into filaments Nat Commun, 2019
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria Exp Cell Res, 2008