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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FAHD1 dimer hydrolyses OA to PYR

OA + H+ → PYR + CO2

Reactome: R-HSA-9012016
Compartment: mitochondrial matrix
Rhea: RHEA:15642

Inputs

OACHEBI:16452, C4H2O5, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Outputs

PYRCHEBI:15361, C3H3O3, mitochondrial matrix
CO2CHEBI:16526, CO2, mitochondrial matrix

Catalysed by

oxaloacetate decarboxylase activity of FAHD1:Mg2+ dimer [mitochondrial matrix]EC 4.1.1.112

Literature

X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880 Biol. Chem., 2004
Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase J. Biol. Chem., 2015