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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Pyruvate kinase dephosphorylates PEP to PYR

ADP + PEP + H+ → ATP + PYR

Reactome: R-HSA-71670
Compartment: cytosol
Rhea: RHEA:18159

Inputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
PEPCHEBI:58702, C3H2O6P, cytosol
H+CHEBI:15378, H, cytosol

Outputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
PYRCHEBI:15361, C3H3O3, cytosol

Catalysed by

pyruvate kinase activity of pyruvate kinase tetramer [cytosol]EC 2.7.1.40

Literature

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis Biochemistry, 2005
cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia Proc Natl Acad Sci U S A, 1991
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription Int J Biochem Cell Biol, 2008
Isolation and characterization of the human pyruvate kinase M gene Eur J Biochem, 1991
Human liver type pyruvate kinase: complete amino acid sequence and the expression in mammalian cells Proc Natl Acad Sci U S A, 1988
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia J Biol Chem, 2002