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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SIRT4 cleaves lipoyl from DLAT

H2O + Lipo-K259-DLAT + NAD+ → 2''-O-lipoyl-ADP-D-ribose + NAM + DLAT

Reactome: R-HSA-9861626
Compartment: mitochondrial matrix
Rhea: RHEA:63641

Inputs

H2OCHEBI:15377, H2O, mitochondrial matrix
Lipo-K259-DLATR-HSA-69969, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Outputs

2''-O-lipoyl-ADP-D-riboseCHEBI:189572, C23H33N5O15P2S2, mitochondrial matrix
NAMCHEBI:17154, C6H6N2O, mitochondrial matrix
DLATR-HSA-6792585, mitochondrial matrix

Catalysed by

lipoamidase activity of SIRT4:Zn2+ [mitochondrial matrix]EC 3.5.1.138

Literature

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity Cell, 2014