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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Purine catabolism

Source-linked purine breakdown. 33 reactions, from Reactome R-HSA-74259.

  1. NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMPAMP, dAMP, GMP, IMP + H2O → Ade-Rib, dA, Gua-Rib, Ino + Pi
  2. (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A](d)AMP, (d)GMP, (d)IMP + H2O → (d)A, (d)G, (d)I + Pi
  3. AMP + H2O => adenosine + orthophosphate [NT5C1B]AMP + H2O → Ade-Rib + Pi
  4. (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)(d)GMP, (d)IMP + H2O → Gu-Rib, dG, Ino, dI + Pi
  5. Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMPADP-D-ribose + H2O → AMP + R5P + 2 H+
  6. Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMPADP-Rib + H2O → AMP + R5P + 2 H+
  7. NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMPH2O + 2-oxo-dATP(4-) → 2-oxo-dAMP(2-) + H+ + PPi
  8. NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMPH2O + 8-oxo-dGTP(4-) → 8-oxo-dGMP(2-) + H+ + PPi
  9. NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMPH2O + 8-oxo-dGTP(4-) → 8-oxo-dGMP(2-) + H+ + PPi
  10. NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMPH2O + 2-oxo-ATP(4-) → 2-oxo-AMP(2-) + H+ + PPi
  11. NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMPH2O + 8-oxo-GDP(3-) → Pi + 8-oxo-GMP(2-) + H+
  12. NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMPH2O + 8-oxo-dGDP(3-) → Pi + 8-oxo-dGMP(2-) + H+
  13. NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMPH2O + 8-oxo-dGDP(3-) → Pi + 8-oxo-dGMP(2-) + H+
  14. NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMPH2O + 8-oxo-dADP(3-) → Pi + 8-oxo-dAMP(2-) + H+
  15. NUDT16 hydrolyses dIDP to dIMPdIDP + H2O → dIMP + Pi + H+
  16. NUDT16 hydrolyses IDP to IMPIDP + H2O → IMP + Pi + H+
  17. ITPA hydrolyses ITP to IMPITP + H2O → IMP + PPi + H+
  18. ITPA hydrolyses XTP to XMPXTP + H2O → XMP + PPi + H+
  19. ITPA hydrolyses dITP to dIMPdITP + H2O → PPi + dIMP + H+
  20. ADPRM hydrolyses ADP-ribose to R5P and AMPADP-D-ribose + H2O → R5P + AMP + 2 H+
  21. PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribosePi + Ino, dI → Hyp + R1P, dRibP
  22. XDH oxidizes hypoxanthine to form xanthineHyp + H2O + O2 → XAN + H2O2
  23. (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)(d)GMP, (d)IMP + H2O → Gu-Rib, dG, Ino, dI + Pi
  24. PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribosePi + G, dG → Gua + R1P, dRibP
  25. Guanine + H2O => Xanthine + NH4+Gua + H2O + H+ → XAN + NH4+
  26. XDH oxidizes xanthine to form urateXAN + H2O + O2 → urate + H2O2
  27. DNPH1 hydrolyses dGMPdGMP + H2O → 2DORP + Gua
  28. XDH dehydrogenates hypoxanthine to form xanthineH2O + Hyp + NAD+ → H+ + NADH + XAN
  29. XDH dehydrogenates xanthine to form urateH2O + NAD+ + XAN → H+ + NADH + urate
  30. NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP8-oxo-dATP(4-) + H2O → 8-oxo-dAMP(2-) + H+ + PPi
  31. NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMPH2O + O(6)-methyl-dGTP(4-) → H+ + O(6)-methyl-dGMP(2-) + PPi
  32. NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMPH2O + N(6)-methyl-dATP(4-) → H+ + N(6)-methyl-dAMP(2-) + PPi
  33. NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMPN(6)-methyl-ATP(4-) + H2O → H+ + N(6)-methyl-AMP(2-) + PPi