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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Nucleotide biosynthesis

De novo purine and pyrimidine pathways that build bases on or attach them to ribose-phosphate scaffolds. 24 reactions, from Reactome R-HSA-8956320.

Formation of phosphoribosyl pyrophosphate amidotransferase tetramer2 PPAT dimer → PPAT tetramer
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramerPPAT tetramer → 2 PPAT dimer
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]GTP + IMP + L-Asp → GDP + Pi + ADS + 2 H+
UMPS dimer decarboxylates OMP to UMPOMP + H+ → UMP + CO2
UMPS dimer transfers phosphoribosyl group to ORO to form OMPORO + PRPP → OMP + PPi
DHODH:FMN oxidises (S)-DHO to orotate(S)-DHO + CoQ → ORO + QH2
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHON-carb-L-Asp + H+ → (S)-DHO + H2O
CAD hexamer transforms CAP to N-carb-L-AspCAP + L-Asp → N-carb-L-Asp + Pi + H+
CAD hexamer transforms L-Gln to CAPHCO3- + L-Gln + 2 ATP + H2O → CAP + L-Glu + 2 ADP + Pi + 2 H+
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphateXMP + L-Gln + ATP + H2O → GMP + L-Glu + 2 H+ + AMP + PPi
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]H2O + IMP + NAD+ → H+ + NADH + XMP
FAICAR => IMP + H2OFAICAR → IMP + H2O
AICAR + 10-Formyl-THF => FAICAR + THFAICAR + 10-formyl-THF → FAICAR + THF
SAICAR => AICAR + FumarateSAICAR → AICAR + FUMA
CAIR + Aspartate + ATP => SAICAR + ADP + PiCAIR + L-Asp + ATP → SAICAR + ADP + Pi + 2 H+
AIR + CO2 => CAIRAIR + CO2 → CAIR + H+
FGAM + ATP => AIR + ADP + PiFGAM + ATP → AIR + ADP + Pi + H+
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + PiN-Formyl-GAR + L-Gln + ATP + H2O → FGAM + L-Glu + ADP + Pi + H+
GAR + 10-Formyl-THF => FGAR + THFPRGA + 10-formyl-THF → N-Formyl-GAR + THF + H+
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + PiPRA + Gly + ATP → PRGA + ADP + Pi + H+
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine 5-phosphoribosylamine + L-glutamate +pyrophosphatePRPP + L-Gln + H2O → PRA + L-Glu + PPi
adenylosuccinate => adenosine 5'-monophosphate + fumarateADS → AMP + FUMA
IMPDH tetramers bind IMPDH inhibitorsIMPDH tetramers + IMPDH inhibitors → IMPDH tetramers:IMPDH inhibitors
DHODH:FMN binds DHODH inhibitorsDHODH:FMN + DHODH inhibitors → DHODH:FMN:DHODH inhibitors