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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

GTP + IMP + L-Asp → GDP + Pi + ADS + 2 H+

Reactome: R-HSA-111524
Compartment: cytosol
Rhea: RHEA:15754

Inputs

GTPCHEBI:37565, C10H12N5O14P3, cytosol
IMPCHEBI:58053, C10H11N4O8P, cytosol
L-AspCHEBI:29991, C4H6NO4, cytosol

Outputs

GDPCHEBI:58189, C10H12N5O11P2, cytosol
PiCHEBI:43474, HO4P, cytosol
ADSCHEBI:57567, C14H14N5O11P, cytosol
2 H+CHEBI:15378, H, cytosol

Catalysed by

adenylosuccinate synthase activity of ADSS, ADSSL1 dimers [cytosol]EC 6.3.4.4

Literature

Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase FEBS Lett, 1992
Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells Mol Cell Biochem, 2005